Jahmyr Gibbs and Derrick Henry lead UPI senior sports writer Alex Butler's Top 50 fantasy football running back rankings for Week 1 of the 2025 NFL season.

Running back Derrick Henry and the Baltimore Ravens will take on the Buffalo Bills in Week 1. File Photo by David Tulis/UPI UPI Running back Jahmyr Gibbs and the Detroit Lions will face the Green Bay Packers at 4:25 p.m. EDT Sunday in Green Bay, Wis. File Photo by Mark Black/UPI UPI San Francisco 49ers running back Christian McCaffrey (C) is among my Top 3 fantasy football options for Week 1. File Photo by Jon SooHoo/UPI UPI Miami Dolphins running back De'Von Achane will take on the Indianapolis Colts on Sunday in Indianapolis. File Photo by Kevin M. Cox/UPI UPI Atlanta Falcons running back Bijan Robinson (7) is among my Top 5 fantasy football options in Week 1. File Photo by A.J. Sisco/UPI UPI

MIAMI, Sept. 5 (UPI) -- Jahmyr Gibbs and Derrick Henry lead my Top 50 fantasy football running back rankings for Week 1 of the 2025 NFL season.

Christian McCaffrey, De'Von Achane and Bijan Robinson are among my other Top 5 plays for Week 1. Ashton Jeanty, Bucky Irving, James Conner, Jonathan Taylor and Josh Jacobs are also inside my Top 10.

My Week 1 wide receiver rankings are available here. Players from Thursday's game between the Philadelphia Eagles and Dallas Cowboys were removed from my rankings.

My position rankings will be updated until Week 1 kickoffs. Players will be removed or adjusted from within my rankings based on injuries.

Week 1 running back rankings

1. Jahmyr Gibbs, Detroit Lions at GB

2. Derrick Henry, Baltimore Ravens at BUF

...

3. Christian McCaffrey, San Francisco 49ers at SEA

4. De'Von Achane, Miami Dolphins at IND

5. Bijan Robinson, Atlanta Falcons vs. TB

6. Ashton Jeanty, Las Vegas Raiders at NE

7. Bucky Irving, Tampa Bay Buccaneers at ATL

8. James Conner, Arizona Cardinals at NO

9. Jonathan Taylor, Indianapolis Colts vs. MIA

10. Josh Jacobs, Green Bay Packers vs. DET

11. Aaron Jones, Minnesota Vikings at CHI

12. Alvin Kamara, New Orleans Saints vs. ARI

13. Chase Brown, Cincinnati Bengals at CLE

14. Kyren Williams, Los Angeles Rams vs. HOU

15. Kenneth Walker III, Seattle Seahawks vs. SF

16. D'Andre Swift, Chicago Bears vs. MIN

17. Chuba Hubbard, Carolina Panthers at JAX

18. James Cook, Buffalo Bills vs. BAL

19. Breece Hall, New York Jets vs. PIT

20. Tony Pollard, Tennessee Titans at DEN

21. Tyrone Tracy Jr., New York Giants at WAS

22. Travis Etienne, Jacksonville Jaguars vs. CAR

23. Omarion Hampton, Los Angeles Chargers vs. KC

24. R.J. Harvey, Denver Broncos vs. TEN

25. TreVeyon Henderson, New England Patriots vs. LV

26. Jaylen Warren, Pittsburgh Steelers at NYJ

27. Jerome Ford, Cleveland Browns vs. CIN

28. Austin Ekeler, Washington Commanders vs. NYG

29. David Montgomery, Detroit Lions at GB

30. Isiah Pacheco, Kansas City Chiefs vs. LAC

31. Rhamondre Stevenson, New England Patriots vs. LV

32. Jacory Croskey-Merritt, Washington Commanders vs. NYG

33. Dylan Sampson, Cleveland Browns vs. CIN

34. Ollie Gordon II, Miami Dolphins at IND

35. J.K. Dobbins, Denver Broncos vs. TEN

36. Jordan Mason, Minnesota Vikings at CHI

...

37. Nick Chubb, Houston Texans at LAR

38. Braelon Allen, New York Jets vs. PIT

39. Kareem Hunt, Kansas City Chiefs vs. LAC

40. Zach Charbonnet, Seattle Seahawks vs. SF

41. Tank Bigsby, Jacksonville Jaguars vs. CAR

42. Ray Davis, Buffalo Bills vs. BAL

43. Rachaad White, Tampa Bay Buccaneers at ATL

44. Kaleb Johnson, Pittsburgh Steelers at NYJ

45. Cam Skattebo, New York Giants at WAS

46. Dameon Pierce, Houston Texans at LAR

47. Najee Harris, Los Angeles Chargers vs. KC

48. Bhayshul Tuten, Jacksonville Jaguars vs. CAR

49. Trey Benson, Arizona Cardinals at NO

50. Rico Dowdle, Carolina Panthers at JAX